Please join us for our BCB faculty seminar today at 4:10 in 1424 Molecular Biology Building.
Our presenters are Walter Moss, BBMB, and Justin Walley, Plant Pathology and Microbiology:
RNA is considered by many to be the primordial molecule of life. The major component of the ribosome—the most ancient organelle, which is shared between all living things—is ribosomal (r)RNA; which also forms the catalytic center necessary for protein production. The instructions needed for producing proteins is encoded within messenger (m)RNA, which is decoded by the ribosome by way of transfer (t)RNA. Beyond the classical RNAs involved in protein synthesis, a wide array of noncoding (nc)RNAs exist that mediate important biological processes: e.g. regulation of gene expression, mRNA splicing, post-transcriptional modification, chromatin structure, and more. In the vast majority of cases, we know almost nothing about the function of ncRNA (the transcriptional “dark matter”); however, function is inferred from the differential expression/processing of ncRNAs (e.g. in diseases such as cancer) or from their evolutionary conservation. An important feature of all functional RNAs, is the central role played by molecular structure. RNAs can fold back on themselves to form complex 2D (base paired) and 3D (atomic arrangement) shapes. These shapes govern how RNAs interact with other biomolecules (e.g. proteins, nucleic acids and small-molecules), form catalytic centers, determine molecular stability (e.g. lifetime) of RNA, and more. The major goal of the Moss Lab is to identify RNA sequences with a high propensity to form structure, deduce their structures, functions, and the roles played by structure.
Area of Expertise: Noncoding RNA discovery; RNA structure and function
- B.S., Chemistry, SUNY Stony Brook
- Ph.D., Chemistry, University of Rochester
3256 Molecular Biology Building
Website: Walter Moss Lab Website
Research in my lab investigates molecular mechanisms that underpin plant-microbe interactions. Our research focuses on immune signaling in corn and Arabidopsis. We specialize in mass spectrometry based proteomics to globally quantify protein abundance and post-translational modifications (including phosphorylation and acetylation). Using systems biology we integrate these data with other types of omics datasets, such as transcriptome profiling, to generate hypotheses to test using various biochemical and genetic approaches.
Area of Expertise: proteomics
- PhD, University of California - Davis, 2009
- MS, Miami University, 2005
- BS, University of Mount Union, 2001
Website: Google Scholar