Sanford Burnham Prebys Medical Discovery Institute
“Autophagy and aging: Lessons from long-lived C. elegans”
Abstract: The cytosolic recycling process of autophagy plays an important role in many age-related diseases and has been directly linked to aging, including in the nematode C. elegans where autophagy appears beneficially induced in many conserved longevity models. As a critical process to ensure cellular homeostasis, autophagy is regulated at multiple levels, yet it remains a challenge in the field to understand how the regulation of autophagy is integrated at the cellular and molecular level to ensure health- and lifespan benefits. I will discuss our progress on understanding the different molecular mechanisms employed by cells and organisms to regulate autophagy in response to stressors such as aging and disease.
Sanford Burnham Prebys (SBP) Medical Discovery Institute:
- Professor — Program for Development, Aging and Regeneration, La Jolla, Calif.
- Associate dean of student affairs — SBP Graduate School of Biomedical Sciences
- Faculty advisor — postdoctoral training in La Jolla
- Neuroscience and Aging Research Center
Host: Hua Bai
Refreshments served at 3:45 p.m. in the MBB Atrium.