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BCB-IGERT-MGET News

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August First Thursday Scheduled for August 7 (7/29/08 ts)
All BCB Graduate Students and IGERT and MGET Fellows are invited to our August First Thursday supper which will be held Thursday, August 7, at 5:30 pm in 1102 Molecular Biology. We hope you will be able to join us as we review BCB program research efforts. Please let Trish know if you will be able to attend.

Baker Seminar Speaker, July 30 (7/28/08 ts)
Dr. Shannon Schlueter, Computer and Information Technology, Purdue University, will present a July 30 seminar hosted by the L.H. Baker Center for Bioinformatics and Biological Statistics and Computational and Systems Biology Summer Institute from 1:10 to 2 p.m. in 1652 Gilman. The title of the seminar is: "Genome Assembly in a High Performance Computing Environment"

Baker Seminar Speaker, July 29 (7/28/08 ts)
Dr. Ken Dill, Pharmaceutical Chemistry, University of California, will present a July 29 seminar hosted by the L.H. Baker Center for Bioinformatics and Biological Statistics and Computational and Systems Biology Summer Institute from 1:10 to 2 p.m. in 1652 Gilman. The title of the seminar is: "Principles of small-numbers dynamics for biology and nanoscience"

A Seminar of Interest to BCBers, August 12 (7/28/08 ts)

Jelle Goeman from the Leiden University Medical Center will speak on "Multiple testing on the directed acyclic graph of Gene Ontology" in 105 Kildee Hall at 4:10 p.m. on Tuesday, August 12. Mark your calendars ! Here is an abstract of the talk:

Methods that test for differential expression of gene groups such as provided by the Gene Ontology database are becoming increasingly popular in the analysis of gene expression data. However, so far methods could not make use of the graph structure of Gene Ontology when adjusting for multiple testing. We propose a multiple testing method, called the focus level procedure, that preserves the graph structure of Gene Ontology (GO) when testing for association of the expression profiles of GO terms with a response variable. The procedure is constructed as a combination of a Closed Testing procedure with Holm's method. It allows a user to choose a "focus level" in the GO graph, which reflects the level of specificity of terms in which the user is most interested. This choice also determines the level in the GO graph at which the procedure has most power. The procedure strongly keeps the family-wise error rate without any additional assumptions on the joint distribution of the test statistics used. We also present an algorithm to calculate multiplicity-adjusted p-values. Because the focus level procedure preserves the structure of the GO graph, it does not generally preserve the ordering of the raw p-values in the adjusted p-values. This is joint work with Ulrich Mansmann.

BCB Symposium Update: June 11 to 14, 2009 (4/28/08 ts)
Plans are underway to hold a symposium entitled: Systems Biology: Integrative, Comparative, and Multi-Scale Modeling, June 11 to June 14, 2009, at the Scheman Education Building in the Iowa State Center. This BCB-related symposium will be one in a long series of Growth Factor and Signal Transduction symposia held at Iowa State and sponsored by the Dept. of BBMB. Several researchers have already accepted our invitation to speak including:

Albert-Laszlo Barabasi
Center for Complex Network Research at Northeastern University
www.barabasi.com or www.physics.neu.edu/Department/Vtwo/faculty/barabasi.htm

Hamid Bolouri
Neural Systems Group, Science & Technology Research Centre
University of Hertfordshire, UK and Division of Biology
California Institute of Technology

Steve Horvath
Biostatistics & Human Genetics UCLA
http://www.biostat.ucla.edu/people/horvath.htm

David Hume
Institute for Molecular Bioscience, University of Queensland
http://www.macrophages.com/content/macrophages/about/david_hume.htm

Maricel Kann
UMBC Department of Biological Sciences
http://umbc.edu/biosci/general/user/mkann

Melissa Kemp
The Wallace H. Coulter Department of Biomedical Engineering
Georgia Tech & Emory University
http://kemp.openwetware.org/Research.html

Teresa Przytycka
NCBI, NLM, NIH
Computational Biology Branch
https://www.ncbi.nlm.nih.gov/CBBresearch/Przytycka

Mona Singh
Department of Computer Science
Lewis-Sigler Institute for Integrative Genomics
Princeton University
http://www.cs.princeton.edu/~mona/

The Symposium will begin with a session on a vision of Systems Biology; past, present, future. The bulk of the Symposium will then cover the Modeling of biological processes at molecular, cellular and organismal levels, and at multiple scales of investigation. The meeting will emphasize both current applications of available modeling tools as well as pioneering research in fundamental aspects of biological modeling.

The Symposium will cover four dates (Thursday June 11- Sunday June 14, 2009) and 16-18 speakers who are world leaders in their respective fields are expected to provide 45-60 minute talks. In addition, 8-10 additional speakers selected from submitted abstracts will give 15-20 minute talks. A poster session will be held to provide an opportunity for students to present their ongoing research.

A unique aspect of this conference is that the conference will be part of the cross-disciplinary training of students in the ISU NSF IGERT training grant in Computational Biology. These IGERT trainees and associates will have access to the wide variety of world-class speakers at this Symposium, as well as other scientists attending. The students will have an opportunity to present their research in a poster session, as well as compete for the opportunity to present a short talk at one of the sessions, and also interact with speakers through assisting with transportation, etc. for the Symposium.

BCB students to present at ISMB in July(7/8/08 ts)
Eight students will be traveling to the ISMB 2008 conference to be held in Toronto, July 19-23. Several have had posters accepted ! Congratulations ! BCB and IGERT are sponsoring the student symposium in conjunction with this major BCB-related symposium. See http://symposium.iscbsc.org/.

BCB Library books can be checked out ! (2/9/08 ts)
There are a number of books that can be checked out from the BCB library located in 2014 Molecular Biology Building. Here is a current list. Those checked out are indicated. Stop by between 10 and 5 p.m. to check one out !

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