Dr. Drena Dobbs

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University Professor
Dr. Drena Dobbs photo

Research Interests - Macromolecular Structure, Function & Dynamics 


Long-term research goals of the Dobbs group are to understand how proteins and nucleic acids achieve their functional three-dimensional structures and to elucidate mechanisms that determine recognition and regulate interactions among proteins, nucleic acids and other molecules in cells.  We have used both computational and wet-lab experimental approaches to explore the structure and function of important macromolecular complexes, in close collaboration with several groups at ISU, Pennsyvania State University, University of Minnesota, the Mayo Clinic, and Harvard University.


Current areas of focus include: providing computational resources to improve efficacy of CRISPR-Cas9 and other designer nucleases for precision genome modification; predicting RNA-protein interactions and interaction networks; predicting and validating of structural and functional effects of mutations and SNPs in both proteins in ncRNAs; comparative genomics.


Recent Representative Publications


Area of Expertise: 
Computational Biology
Macromolecular Structure Function & Dynamics
RNA
Education: 
B.S., Biology, University of Georgia, 1977
Ph.D., Molecular Biology, University of Oregon, 1983
NIH Postdoc, University of California, Berkeley, 1983-1987
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