Dr. Edward Yu, Professor, received his Ph.D. from the University of Michigan at Ann Arbor in 1997. After working as an NIH postdoctoral fellow at University of California-Berkeley, Dr. Yu joined the faculty at Iowa State University in 2004. He is currently a professor of Chemistry and of Physics & Astronomy. Dr. Yu's research focuses on elucidating the structure and function of membrane proteins using x-ray crystallography.
We currently focus on studying bacterial antibiotic resistance mediated by active multi-drug efflux transporters. Our long-term goal is to elucidate the structures and fundamental mechanisms that give rise to multiple drug recognition and extrusion in these multi-drug transporters. In addition, our laboratory addresses fundamental questions regarding the nature of multi-drug recognition and gene regulation in transcriptional regulators. These regulators control the expression of multi-drug efflux transporters in bacteria by sensing the presence of a variety of structurally unrelated toxic compounds in the environment. Our experimental approach mainly utilizes x-ray crystallography to elucidate toxic chemical binding and export by these membrane efflux transporters.