Professor Trimarchi received his B.A. in Biology from Amherst College in 1993. In 2001 he received his Ph.D. from the Massachusetts Institute of Technology, where his mentor was Dr. Jacqueline Lees. He was a postdoctoral research fellow at Harvard Medical School, where his mentor was Dr. Constance Cepko. Dr. Trimarchi joined the Genetics, Development and Cell Biology Department faculty at Iowa State University in spring 2010.
The goal of my laboratory is to develop a systems level understanding of the development and degeneration of neurons. Single cell transcriptomics in conjunction with gain and loss of function experiments are utilized to identify the gene expression networks responsible for generating neuronal diversity in the developing mouse, zebrafish and chicken retina, specifically among the retinal ganglion cells. These data can be used to enhance the efficiency with which ganglion cells are generated for potential uses in therapies for optic neuropathies such as glaucoma. A second avenue of research in the lab uses the same single cell technology to examine motor neurons that are resistant to the disease-causing mechanisms of Amyotrophic Lateral Sclerosis (ALS). These experiments will identify new potential drug targets for intervention in ALS patients.