Dr. Jon P Mochel

People
Associate Professor of Pharmacology
European Veterinary Specialist in Pharmacology and Toxicology
Photo of Jonathan Mochel
Department: 

Education and Certifications

  • Veterinary Degree (DEFV): 2006
  • Masters in Clinical Pharmacology and Pharmacokinetics: 2006
  • Doctorate in Veterinary Medicine (DVM): 2007
  • Small Animal Internal Medicine and Surgery Internship: 2008
  • Master of Sciences in Pharmacology (MSc): 2009
  • Pharmacology and Toxicology Residency (Dipl. ECVPT): 2013
  • PhD in Pharmacology: 2015

Research Focus and Interests

  • Clinical Pharmacology
  • Pharmacokinetics and Pharmacodynamic Modeling
  • Cardiovascular Research
  • Translational Medicine (One Health)

Memberships

  • Co-Founder and President, Animal Health Modeling and Simulation Society
  • Fellow, American Academy of Veterinary Pharmacology and Therapeutics
  • Counselor, American Academy of Veterinary Pharmacology and Therapeutics
  • Member, International Society of Pharmacometrics
  • Member, American Association of Pharmaceutical Scientists
  • Member, American Gastroenterology Association
  • Member, European Association for Veterinary Pharmacology and Toxicology
  • Member, European Federation for Pharmaceutical Sciences, Network on Veterinary Medicines
  • Member, Charitable organization Notre-Dame de Lourdes

Selected Publications (last 4 years)

  • Bieth B, Bornkamp B, Toutain C, Garcia R, Mochel JP. Multiple comparison procedure and modeling: a versatile tool for evaluating dose-response relationships in veterinary pharmacology - a case study with furosemide. J Vet Pharmacol Ther. 2016 Dec;39(6):539-546. doi: 10.1111/jvp.12313. PubMed [citation] PMID: 27166146 
  • Pelligand L, Soubret A, King JN, Elliott J, Mochel JP. Modeling of Large Pharmacokinetic Data Using Nonlinear Mixed-Effects: A Paradigm Shift in Veterinary Pharmacology. A Case Study With Robenacoxib in Cats. CPT Pharmacometrics Syst Pharmacol. 2016 Oct 22. doi: 10.1002/psp4.12141. [Epub ahead of print] PubMed [citation] PMID: 27770596 
  • Lin Z, Gehring R, Mochel JP, Lavé T, Riviere JE. Mathematical modeling and simulation in animal health - Part II: principles, methods, applications, and value of physiologically based pharmacokinetic modeling in veterinary medicine and food safety assessment. J Vet Pharmacol Ther. 2016 Oct;39(5):421-38. doi: 10.1111/jvp.12311. Review. PubMed [citation] PMID: 27086878 
  • Dencker L, Hellmann K, Mochel JP, Senel S, Linden Hans, Vendrig D, Schmerold I Position Paper: EUFEPS Network on Veterinary Medicines Initiative. Eur J Pharm Sci. 2016 Aug 25; 91:I-VII. 
  • Riviere JE, Gabrielsson J, Fink M, Mochel J. Mathematical modeling and simulation in animal health. Part I: Moving beyond pharmacokinetics. J Vet Pharmacol Ther. 2016 Jun;39(3):213-23. doi: 10.1111/jvp.12278. Review. PubMed [citation] PMID: 26592724 
  • Mochel JP, Fink M, Peyrou M, Soubret A, Giraudel JM, Danhof M. Pharmacokinetic/Pharmacodynamic Modeling of Renin-Angiotensin Aldosterone Biomarkers Following Angiotensin-Converting Enzyme (ACE) Inhibition Therapy with Benazepril in Dogs. Pharm Res. 2015 Jun;32(6):1931-46. doi: 10.1007/s11095-014-1587-9. PubMed [citation] PMID: 25446774 
  • Mochel JP, Danhof M. Chronobiology and Pharmacologic Modulation of the Renin-Angiotensin-Aldosterone System in Dogs: What Have We Learned? Rev Physiol Biochem Pharmacol. 2015;169:43-69. doi: 10.1007/112_2015_27. Review. PubMed [citation] PMID: 26428686 
  • Mochel JP, Fink M, Bon C, Peyrou M, Bieth B, Desevaux C, Deurinck M, Giraudel JM, Danhof M. Influence of feeding schedules on the chronobiology of renin activity, urinary electrolytes and blood pressure in dogs. Chronobiol Int. 2014 Jun;31(5):715-30. doi: 10.3109/07420528.2014.897711. PubMed [citation] PMID: 24654920 
  • Mochel JP, Fink M, Peyrou M, Desevaux C, Deurinck M, Giraudel JM, Danhof M. Chronobiology of the renin-angiotensin-aldosterone system in dogs: relation to blood pressure and renal physiology. Chronobiol Int. 2013 Nov;30(9):1144-59. doi: 10.3109/07420528.2013.807275. PubMed [citation] PMID: 23931032 
  • Fink M, Letellier I, Peyrou M, Mochel JP, Jung M, King JN, Gruet P, Giraudel JM. Population pharmacokinetic analysis of blood concentrations of robenacoxib in dogs with osteoarthritis. Res Vet Sci. 2013 Oct;95(2):580-7. doi: 10.1016/j.rvsc.2013.04.021. PubMed [citation] PMID: 23726662 
  • Mochel JP, Gabrielsson J, Collard W, Fink M, Gehring R, Laffont C, Liu Y, Martin-Jimenez T, Pelligand L, Steimer JL, Toutain PL, Whittem T, Riviere J. Animal Health Modeling & Simulation Society: a new society promoting model-based approaches in veterinary pharmacology. J Vet Pharmacol Ther. 2013 May 29. doi: 10.1111/jvp.12060. [Epub ahead of print] PubMed [citation] PMID: 23713757 
  • Mochel JP, Peyrou M, Fink M, Strehlau G, Mohamed R, Giraudel JM, Ploeger B, Danhof M. Capturing the dynamics of systemic Renin-Angiotensin-Aldosterone System (RAAS) peptides heightens the understanding of the effect of benazepril in dogs. J Vet Pharmacol Ther. 2013 Apr;36(2):174-80. doi: 10.1111/j.1365-2885.2012.01406.x. PubMed [citation] PMID: 22568394 
  • Mochel JP, Fink M. Response to letter from Atkins et al. Capturing the dynamics of systemic Renin-Angiotensin-Aldosterone System (RAAS) peptides heightens the understanding of the effect of benazepril in dogs J Vet Pharmacol Ther. 2012 Sept 11; 35:516-518.
Area of Expertise: 
Pharmacology
Toxicology
Education: 
PhD, Pharmacology and Toxicology, Leiden University, The Netherlands, 2014
Contact
515-294-7424
2448 Lloyd, 1809 S. Riverside Drive
Ames
Iowa
50011-1250