Julien Roche

People
Assistant Professor

We study the mechanisms of folding, activation, fibrillation and evolution of proteins involved in neurodegenerative and infectious diseases. We use a combination of Nuclear Magnetic Resonance (NMR) spectroscopy, X-ray crystallography, molecular dynamics simulations and bioinformatics techniques to characterize the structural and functional properties of these proteins at an atomistic level. The detailed characterization of these complex mechanisms provides a molecular basis for the development of new therapeutic approaches.

Related projects include the study of intrinsically disordered proteins, the characterization of amyloid-type peptides and the development of coarse-grained methods for protein folding simulations.

Area of Expertise: 
Protein folding
design
Evolution
Education: 
B.S., Biology, Univ. of Montpellier, France
M.S., Biophysics, Univ. of Montpellier, France
Ph.D., Center for Structural Biology, Montpellier, France
Contact
515-294-6437
3116 Molecular Biology Building
Ames
Iowa
50011-