Dr. Nick Serao

People
Assistant Professor
Department: 

Nick V.L. Serão, Ph.D.

Assistant Professor, Animal Breeding & Genetics

Research Interests:

Quantitative genetics and genomics of disease/stress response and fertility in livestock animals; QTL mapping; Genomic prediction/selection; Gene expression analysis; Statistical methods for genomic analyses; Big Data; Modeling of immune response, and infectious diseases

Description of current and future research:

In my current research program, my group makes use of phenotypic and genomic data in order to improve the understanding of complex traits in animals and plants. Phenotypic traits use in my research follow a variety of distributions (quantitative/categorical), sources (e.g. performance, gene expression, metabolomics, proteomics, etc), and patterns (e.g. longitudinal). Genomic data used in my research include high-density genotypes and gene expression. With these types of data, in my group we perform QTL and eQTL mapping, genomic prediction, network and enrichment analyses, and more.

In addition to the use of real data, in my group we make use of simulation in order to evaluate the use of new/alternative methods that can improve the accuracy of QTL mapping and genomic prediction. Moreover, we use simulated data to evaluate alternative breeding strategies with the objective of improving response to selection for novel traits (e.g. disease resitance in pigs).

With the advances in –omics technologies and generation of multiple sources of information, in my future research I would like to work with DNA sequence for fine mapping of previously QTL identified in my work, as well as epigenomic data. Moreover, I want to evaluate and develop statistical methodologies that can make simultaneous use of different sources of information (e.g. DNA, RNA, metabolomics, performance, etc) in order to improve QTL mapping and genomic prediction. In other words, continue doing work on machine learning/big data, including several sources of information.

Education:        Ph.D. (Animal Science), University of Illinois at Urbana-Champaign, 2012

                        M.S. (Animal Breeding and Genetics), Federal University of Viçosa, Brazil, 2009

                        B.S. (Animal Science), Federal University of Viçosa, Brazil, 2007

Position and Experience:

2017 – Present           Assistant Professor, Iowa State University

2015 – 2017               Assistant Professor, North Carolina State University

2013-2015                 Postdoctoral Research Associate, Iowa State University

Recent Publications (underlined students/visiting scientists under my mentoring):

  • Nascimento M, FF Silva, T Sáfadi, ACC Nascimento, TEM Ferreira, LMA Barroso, CF Azevedo, SEF Guimarães, NVL Serão (2017) ICAclust: a tool for clustering of temporal RNA-Seq data. PLOS One (in press).
  • Bueno R, C Campos, R Veroneze, W Silva, LMP Sanglard, NVL Serão, G Hausman, M Dodson, MS Duarte (2017) Technical Note: A comparison among adipogenic induction protocols for dedifferentiated fat (DFAT) cells obtained from subcutaneous fat of pigs. Livestock Science (in press).
  • Dunkelberger JR, NVL Serão, NC Niederwerder, MA Kerrigan, JK Lunney, RRR Rowland, JCM Dekkers (2017) Effect of a major QTL for PRRS-resistance on response to co-infection with PRRS virus and PCV2b in commercial pigs, with or without prior vaccination for PRRS. Journal of Animal Science, 95(2):584-98.
  • Waide EH, CK Tuggle, M. Schroyen, NVL Serão, A Hess, RRR Rowland, JK Lunney, GS Plastow, JCM Dekkers (2017) Genomewide association of piglet responses to infection with one of two isolates of the porcine reproductive and respiratory syndrome virus. Journal of Animal Science, 95(1):16.
  • Benedeti PBB, BC Silva, MVC Pacheco, IC Filho, MM Lopes, W Silva, NVL Serão, E Detmann, SC Valadares Filho, MS Duarte (2017) Grain Processing Effects on Expression of Genes Involved in Volatile Fatty Acid Transport in Rumen Epithelium of Beef Cattle. ASAS-CSAS Annual Meeting & Trade Show, Baltimore, MD, USA, 2017. (accepted - abstract)
  • Benedeti PBB, MM Lopes, SFM Bonilha, NVL Serão, DRG Lopes, W Silva, HC Mantovani, CJ Newbold, ED, MS Duarte (2017) Expression of Genes Involved in Metabolism and Volatile Fatty Acids and Urea Transport in Rumen Epithelium of Bulls Identified for High, Medium, and Low Residual Feed Intake. ASAS-CSAS Annual Meeting & Trade Show, Baltimore, MD, USA, 2017. (accepted - abstract)
  • Sanglard LMP*, M Nascimento*, P Moriel, M Ashwell, MH Poore, MS Duarte, NVL Serão (2017) Effect of maternal nutrition and sex on skeletal muscle gene expression in Angus cattle during immune challenge. ASAS-CSAS Annual Meeting & Trade Show, Baltimore, MD, USA, 2017. (accepted - abstract)
  • Dunkelberger JR, NVL Serão, Z Weng, MC Niederwerder, EH Waide, MA Kerrigan, JK Lunney, RRR Rowland, JCM Dekkers (2017) Biological evidence for genomic regions associated with host response to co-infection with PRRS virus and PCV2b in commercial nursery pigs. In: Journal of Animal Sciences, 95(Suppl. 5):16. ADSA®-ASAS Joint Midwest Meeting, Omaha, NL, USA, 2017 (abstract).
  • See G, NVL Serão, M Knauer (2017) Genetic parameters for age at puberty in sows. In: Journal of Animal Sciences, 95(Suppl. 5):20. ADSA®-ASAS Joint Midwest Meeting, Omaha, NL, USA, 2017 (abstract).
  • Ferring CL*, KA Gray, NVL Serão (2017) Reaction norms for reproductive performance during PRRS and PED outbreaks. In: Journal of Animal Sciences, 95(Suppl. 5):16-17. ADSA®-ASAS Joint Midwest Meeting, Omaha, NL, USA, 2017 (abstract).
  • Barroso LMA*, F Morgante, TFC Mackay, ACC Nascimento*, M Nascimento*, NVL Serão (2017) Genomic prediction accuracies using regularized quantile regression (RQR) methodology. In: Journal of Animal Sciences, 95(Suppl. 5):14-15. ADSA®-ASAS Joint Midwest Meeting, Omaha, NL, USA, 2017 (abstract).
  • Nascimento M*, ACC Nascimento*, W Cai, JCM Dekkers, NVL Serão (2017) Genetic parameters and trends for residual feed intake (RFI), performance traits, and growth curve parameters in pigs selected for low RFI with contrasting growth trajectories. In: Journal of Animal Sciences, 95(Suppl. 5):15. ADSA®-ASAS Joint Midwest Meeting, Omaha, NL, USA, 2017 (abstract).
  • Mayberry KJ, TL Devine, MH Poore, NVL Serão, DH Poole (2017) Evaluation of Angus Cattle Hair Coat Length and its effect on Tolerance to Fescue Toxicity. In: Journal of Animal Sciences, 95(Suppl. 1):40. ASAS Southern Section Meeting, Franklin, TN, USA, 2017 (abstract).
  • Khanal P*, KJ Mayberry, MH Poore, DH Poole, NVL Serão (2017) Effect of genetic response to fescue toxicity on body weight, body temperature, hair coat, hair shed and body condition score in Angus cows. In: Journal of Animal Sciences, 95(Suppl. 1):18-19. ASAS Southern Section Meeting, Franklin, TN, USA, 2017 (abstract).
  • Galliou JM*, P Khanal, KJ Mayberry, MH Poore, DH Poole, NVL Serão (2017) Evaluating the accuracy of a new commercial genetic test for response to fescue toxicosis in cattle. In: Journal of Animal Sciences, 95(Suppl. 1):55-56. ASAS Southern Section Meeting, Franklin, TN, USA, 2017 (abstract).
Area of Expertise: 
Animal Breeding and Genetics
Education: 
Ph.D., University of Illinois at Urbana-Champaign, 2012, Animal Science
Contact
515-294-3435
239B Kildee Hall,
Ames
Iowa
50011-