The Bioinformatics and Computational Biology (BCB) Program at Iowa State University is an interdepartmental graduate major offering outstanding opportunities for graduate study. Over 70 nationally and internationally known faculty take part in the BCB program including biologists, computer scientists, engineers, mathematicians, physicists and statisticians – all who participate in a wide range of collaborative research projects.
Over 50 graduate students in the BCB Program have the opportunity to conduct research, with access to some of the most modern experimental platforms, in nine related areas of focus: Structural Bioinformatics, Comparative Genomics, Transcriptomics, Proteomics, Predictive Plant Phenomics, Metabolomics, Machine Learning, Image Processing, and Biological Data Mining, modeling and analytics.
An Overview of the BCB Graduate Program
An overview of the BCB program is here. It contains information on faculty, research emphasis, courses, the rotation program, degree and course requirements and a training timeline. The Ph.D. and M.S. degrees are usually completed in five and two years, respectively.
The BCB Training Program
BCB students are trained to develop an independent and creative approach to science through an integrated curriculum and interdisciplinary research projects in all major research areas of computational molecular biology, including genomics, metagenomics, structural genomics, functional genomics, phylogenetics, and computational systems biology, with access to some of the most modern experimental platforms.
First-year students receive graduate research assistantships and participate in research rotations in three or more laboratories to gain experience in both "wet" and "dry" lab environments and to find the laboratory in which they will do their PhD research. More fellowships are available via various sources, including a recently awarded NSF training grant for predictive plant phenomics.
In the second year, students initiate a thesis research project under the guidance of two faculty mentors, the major and co-major professor, one from the biological sciences and one from the quantitative/computational sciences.
Program of Study (POS) Committee
After choosing the major and co-major professor, students begin planning a suitable program for completion of the BCB graduate coursework. Before the end of the first year, students determine the remainder of their Program of Study (POS) Committee members through discussions with their major and co-major professors.
Among the committee’s duties are:
- reviewing periodically the progress of the student;
- advising a student during the development of the thesis, or the dissertation;
- considering and approving the student’s program of study as well as changes in the program of study;
- reading the thesis, or dissertation; and
- conducting the preliminary oral examination (for Ph.D. candidates) and the final oral examination (for master’s and Ph.D. candidates).
One form will be filed electronically with the Graduate College to form the POS Committee and to report the courses the student will take to complete their graduate coursework for their POS. More information on the POS Committee is here.
Advanced degrees in BCB require that a student's research project be interdisciplinary, including both novel biological and quantitative/computational components. The POS committee is responsible for determining whether a student's research project meets this condition.
Research expectations in the BCB Graduate Program continue to grow. BCB is a dynamic discipline and advances in knowledge are dramatic. As a maturing discipline, students and faculty should discuss both the novel computational components of the research being pursued as well as the novel biological components and report on this dual aspect of research progress at the annual program of study meetings with the student and POS committee. Examples of this duality in novel computational and biological components of BCB research are described here.
You are the Expert: A PhD Dissertation
In BCB, the Ph.D. thesis is generally written in an alternate journal format which includes approximately three published or publishable original manuscripts.
According to the Graduate College Handbook: "A doctoral dissertation must demonstrate conclusively the ability of the author to conceive, design, conduct, and interpret independent, original, and creative research. It must attempt to describe significant original contributions to the advancement of knowledge and must demonstrate the ability to organize, analyze, and interpret data. In most instances, a dissertation includes a statement of purpose, a review of pertinent literature, a presentation of methodology and results obtained, and a critical interpretation of conclusions in relation to the findings of others. When appropriate, it involves a defense of objectives, design, and analytical procedures. Dissertation research should be worthy of publication and should appear in appropriate professional journals or in book form.
"Since satisfactory completion of the thesis or dissertation can constitute one of the most gratifying experiences in graduate study, the document should reflect the highest standards of scholarship, serving as a measure of quality for the student, major professor, the program, and Iowa State University.
"Responsibility for writing and editing of the thesis or dissertation rests with the student, under the supervision of the major professor, and not with the Graduate College. The Graduate College does not permit joint authorship of theses or dissertations. It is the responsibility of the major professor to supervise the preparation of preliminary and final drafts of the thesis or dissertation, so as to assure the highest level of quality when the student presents the thesis or dissertation to the committee for final approval."
Degree Requirements for the BCB Program
Comprehensive information on how to progress through the BCB degree program at Iowa State University can be found throughout this website and here.