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Iowa State University

Yuan Lin

Bioinformatics & Computational Biology M.S. Candidate

The Relationship of Sequence Similarity and Expression Pattern Similarity between Yeast Genes within Gene Families

Yuan Lin
BCB
Iowa State University
Wedsday November 28, 2001
10:00-11:00 a.m.
333 Science II

Abstract
After gene duplication, the sequence and expression patterns of duplicated genes diverge. It is known that the function divergence of duplicated genes could be related to the divergence of both their coding sequence and expression profile mainly caused by the sequence change of regulatory region. But it is not known if the sequence divergence and expression pattern divergence are correlated. Former research by Andreas Wagner showed there is at most very weak correlation between them. On the contrary, our research shows there is a strong correlation between the sequence similarity and expression profile similarity if the sequences are quite conserved; the degree of coexpression of duplicated genes is consistent to their duplication order.


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