Divita Mathur will present for her dissertation defense on March 21 at 9 a.m. in 1062 Carver Co-Lab. Please feel free to attend. Her mentors are Eric Henderson in the Department of Genetics, Development and Cell Biology and Jack Lutz, Computer Science Department. The title and abstract of her dissertation are below.
Title: Dynamic self-assembling DNA nanosystems: Design and engineering
Abstract: Over the last twenty years, DNA has proven to be a great candidate for engineering nanoscale architectures. These DNA nanostructures have been applied in areas such as single-molecular analyses, nanopatterning, diagnostics and therapeutics.One of the most commonly-used techniques to engineer DNA-based two- and three-dimensional functional nanostructures is DNA origami, wherein a long singlestranded DNA (called scaffold) is folded into a predetermined shape with the help of a set of shorter oligonucleotides (called staples).
This thesis discusses a brief overview of DNA nanotechnology (design, assembly and applications) and three primary projects undertaken in the area of dynamic self-assembling DNA nanosystems:1, a self-assembly design strategy that vastly expands the utility of DNA origami, 2, a DNA origami-based reconfigurable nanosystem with potential as a force/energy balance and diagnostic tool, and 3, a collaborative initiative on computational analyses and experimental verification for improving effiency of DNA nanoengineering.