GDCB Seminar

Tuesday, August 23, 2016 - 4:00pm
Event Type: 

Genetics, Development and Cell Biology (GDCB) Seminar
Tuesday, August 23, 2016
4:10 P.M.

1414 Molecular Biology Building

John A. Cooper
Biochemistry and Molecular Biophysics
Washington University
St. Louis

Actin Assembly at Membranes: Mechanism and Regulation

Actin filaments assemble in cells in order to create structures and drive movements. Filaments often assemble in association with membranes, including the plasma membrane. Membrane--‐derived signals stimulate the activity of regulators that drive actin subunits to polymerize and that cause actin filaments to associate into networks. Actin filaments assemble by adding subunits to their ends, and assembly is regulated by proteins that cap the filament ends. A diverse set of multidomain proteins regulate these actin “capping” proteins and link membranes to actin assembly. Our lab has focused primarily on the CARMIL family of these regulators, combining biochemistry and cell biology to investigate the molecular functions of CARMIL proteins in cells.

Refreshments in the MBB atrium at 3:45 PM before the seminar