GDCB Seminar

Tuesday, August 30, 2016 - 4:00pm
Event Type: 

GDCB Seminar

4:10 PM, Tuesday, Aug 30, 2016
1414 Molecular Biology Bldg

Wei-Lih Lee
Biology Department
University of Massachusetts, Amherst

Regulation of dynein function during mitosis

During development, metaphase spindles undergo large movement or rotation to specify the orientation of cell division axis. Although much has been learned about how spindle translocation is mediated by cortical pulling forces, how spindle integrity is maintained during spindle translocation is less clear. In budding yeast, we have proposed a model for spindle orientation wherein the mitotic spindle protein She1 promotes spindle translocation across the bud neck by polarizing cortical dynein pulling activity. However, whether She1 has any role on the spindle during spindle translocation is unclear. In this seminar, I will present data that offer insights into a regulatory mechanism involving She1 and Ipl1, the yeast Auora B, in the maintenance of spindle stability during dynein--ÔÇÉmediated spindle positioning process.

Join us for refreshments in the MBB atrium at 3:45 PM before the seminar

Host: Mohan Gupta (