Buck Institute for Research on Aging, Novato, CA
Leibniz Institute for Aging Research, Jena, Germany
Age-related Stem Cell Dysfunction: Causes and Consequences
Proliferation of stem cells has to be carefully controlled to maintain long--‐term regenerative capacity of high--‐turnover tissues while preventing cancer. We study the Drosophila intestine as a genetically accessible model in which to explore stem cell function. Our work focuses on the regulation of intestinal stem cell (ISC) proliferation by stress and growth factor signaling. ISCs over--‐ proliferate in aging flies, limiting lifespan. In recent work, we have explored some of the underlying causes of the hyper--‐proliferative phenotype, and have established a role for age--‐related immunosenescence and associated commensal dysbiosis in this breakdown of homeostasis. Our findings deepen our understanding of the regulation of proliferative homeostasis in aging barrier epithelia, and suggest potentially conserved mechanisms by which proliferative homeostasis can be preserved in the long term, extending lifespan.
Join us for refreshments in the MBB atrium at 3:45 PM before the seminar
Host: Hua Bai (email@example.com)