Engineering of Robust Microbial Cell Factories
BCB Faculty member in the Department of Chemical and Biological Engineering
Production of biorenewable fuels and chemicals by microbial cell factories is often limited by product toxicity or inhibitory components of the biomassderived sugars. This toxicity can be addressed by detoxification of the feed stream, in situ removal of the product or increasing the resistance of the microbial biocatalyst. The Jarboe group has used evolutionary and rational strain improvement methods to increase the robustness of Escherichia coli.
This talk will discuss our work to increase production of the bulk biorenewable chemicals styrene and fatty acids, and utilization of thermochemically depolymerized biomass, with a focus on engineering of the microbial cell membrane.