Genetics, Development and Cell Biology
Developmental Genetics of Tube Formation in Zebrafish
Angiogenesis represents a specialized type of vascularization whereby new vessels are formed by the budding of endothelial cells from existing vessels. This allows the tumor to receive nourishment for further growth and provides a route for cancer cells to metastasize to other parts of the body. During angiogenesis, endothelial cells must first sprout from existing vessels by passing through the vessel basement membrane, migrate and divide, and undergo tube formation. Recent advances in our understanding of vascular morphogenesis from in vitro studies have defined distinct signaling pathways and processes utilized during tubulogenesis. However, the mechanisms and pathways utilized in vivo during tubulogenesis are less clear. Our research strategy leverages both transgenics and genome editing in zebrafish to examine vascular tube formation during angiogenesis. By modeling this in zebrafish, we have identified several genes involved in vascular tube formation. We show that VE-Cadherin plays a critical regulatory role in formation of polarity in the luminal membrane and initiation of lumen morphogenesis.
Join us for refreshments in the MBB atrium at 3:45 PM before the seminar
Host: Jo Anne Powell-Coffman (firstname.lastname@example.org)