GDCB Seminar - Mark Estelle

Tuesday, November 14, 2017 - 4:10pm
Event Type: 

GDCB Seminar

Department of Genetics, Development and Cell Biology


Mark Estelle
University of California San Diego
Distinguished Professor and Chair, Section of Cell and Developmental Biology

‘Auxin transcriptional networks from beginning to end’

Abstract: Auxin controls growth and diverse physiological processes through a complex gene regulatory network that includes thousands of genes. Auxin regulates gene expression by promoting the degradation of transcriptional repressors called Aux/IAA proteins. The Aux/IAAs repress transcription by interacting with AUXIN RESPONSE FACTOR (ARF) transcription factors and recruiting members of the TOPLESS (TPL) family of co-repressors to the chromatin. The 29 Aux/IAA genes in Arabidopsis exhibit unique but partially overlapping patterns of expression. Although some studies have suggested that individual Aux/IAA genes have specialized function, genetic analyses of the family have been limited by the lack of loss-of-function phenotypes, presumably because of overlapping function. Further, with a few exceptions, our knowledge of the factors that regulate Aux/IAA expression is limited. We have recently shown that several Aux/IAA proteins are required for drought tolerance in Arabidopsis. Surprisingly, the role of the Aux/IAAs in this instance appears to be to regulate glucosinolate biosynthesis.

Host: Dior Kelley,

Please join us for refreshments outside Room 1414, Molecular Biology Building, at 3:45 p.m.