GDCB Seminar - Michael Soares

Tuesday, August 22, 2017 - 4:10pm
Event Type: 

The fall 2017 GDCB Seminar series begins today (Tuesday, Aug. 22)...below is a complete schedule for the Fall semester.

Dr. Michael J. Soares of the University of Kansas Medical Center will present August 22 on “Plasticity, invasive trophoblast, and placental health” at 4:10 p.m. in Room 1414 of the Molecular Biology Building. Dr. Soares' affiliations include:  Institute for Reproduction and Perinatal Research Departments of Pathology and Laboratory Medicine and Pediatrics, University of Kansas Medical Center, Kansas City, Kansas; Fetal Health Research, Children’s Research Institute, Children’s Mercy, Kansas City, Missouri.

Hosting Dr. Soares’ visit is Assistant Professor and Gregory L. and Kathleen C. Geoffroy Faculty Fellow Geetu Tuteja. Join us before the seminar at 3:45 p.m. for refreshments.

Abstract: Hemochorial placentation is orchestrated through highly regulated temporal and spatial decisions governing the fate of trophoblast stem/progenitor cells. Trophoblast cell acquisition of specializations facilitating invasion and uterine spiral artery remodeling is a labile process, sensitive to the environment, and represents a process that is vulnerable to dysmorphogenesis in pathologic states. Invasive trophoblast cells exit the placenta and move into the uterine stroma through interstitial and endovascular routes. These developmental processes are conserved in rat and human placentation. The rat exhibits deep intrauterine trophoblast invasion and is an experimentally tractable model for investigating mechanisms controlling trophoblast-directed changes in the uterine vasculature. Elements of these developmental events can be modeled and hypotheses tested in rat trophoblast stem cells and in genetically-manipulated rats. Hypoxia can be used as a tool to elucidate acquisition of the invasive trophoblast phenotype. Placental adaptations to environmental challenges highlight the importance of plasticity in safeguarding a healthy pregnancy. (Supported by grants from the NIH HD020676 and HD079363.)

GDCB Seminar Schedule
Fall 2017

Aug. 22 Michael J. Soares, University of Kansas Medical Center (Host: Geetu Tuteja)
Aug. 29 R. Keith Slotkin, The Ohio State University (Host: Erik Vollbrecht)
Sept. 5 Malene Hansen, Sanford Burnham Prebys Medical Discovery Institute (Host: Hua Bai)
Sept. 8* Maura McGrail, Iowa State University *Special Friday seminar, 4:10 p.m. in Room 1414, MBB
Sept. 12 Kristen Kwan, The University of Utah (Host: Jeff Trimarchi)
Sept. 19 Ram Dixit, Washington University in St. Louis (Host: Steve Howell)
Sept. 22* Carolyn Lawrence-Dill, Iowa State University *Special Friday seminar, 4:10 p.m. in Room 1414, MBB
Sept. 26 Matthew Jenks, West Virginia University (Host: Marna Yandeau-Nelson)
Sept. 29* Bing Yang, Iowa State University *Special Friday seminar, 4:10 p.m. in Room 1414, MBB
Nov. 7 Linda M. Hendershot, St. Jude Children’s Research Hospital (Host: Steve Howell)
Nov. 14 Mark Estelle, University of California San Diego (Host: Dior Kelley)
Nov. 21 Fall Break
Nov. 28 Grant Hennig, University of Vermont (Host: Julie Kuhlman)
Dec. 5 Amy Toth, Iowa State University (Host: Marna Yandeau-Nelson)