GDCB Seminar - Takashi Mikawa

Tuesday, November 28, 2017 - 4:10am
Event Type: 

The Tuesday, Nov. 28, Department of Genetics, Development and Cell Biology (GDCB) Seminar will feature Dr. Takashi Mikawa from the University of California San Francisco School of Medicine at 4:10 p.m. in Room 1414 of the Molecular Biology Building. Dr. Mikawa is a professor at UC San Francisco’s Cardiovascular Research Institute. He will present “An apoptosis-mediated barrier at the midline patterns ipsilateral gastrulation in the amniote.”

Abstract: Bilaterality is a major body plan in metazoan phyla. Cells either of the left or right side of bilaterians rarely cross the midline body plane throughout life as evidenced by a naturally occurring mutation, condition of Gynandroph. It has been a longstanding mystery how this evolutionally conserved ipsicaterlaity in the Bilaterians. We show that a caspase-3 dependent programmed death plays a crucial role for the ipsilaterlarity in the amniotes. Using the developing chick embryo as a model, we found that cell death along the midline of the primitive streak, a conduit of amniote gastrulation, prevents contralateral cellular ingression. Suppression of Caspase-3 removes the midline cell death program and allows gastrulation cells to ingress into the contralateral side of the body. These results highlight an active role of cell death to establish a barrier that underlie the morphogenetic organization of patterning in avians.

Host: Julie Kuhlman (

Join us before the seminar at 3:45 p.m. for refreshments. Department of GDCB Assistant Professor Julie Kuhlman ( is the host for Dr. Mikawa’s seminar and visit.