New Book, Protein Actions, has been published

February 16, 2017

New Book has been published

Protein Actions, Principles and Modeling, a book by Ivet Bahar, University of Pittsburgh School of Medicine, Robert L Jernigan, Iowa State University and Ken A. Dill, Laufer Center for Physical and Quantitative Biology, Sony Brook University has just been published by Garland Science.  Ken, Ivet and Bob are pictured below at the recent Biophysical Society 61st Annual Meeting in New Orleans where it appeared.  Jernigan is a BCB faculty member in the BBMB Department at Iowa State.

Ken Dill, Ivet Bahar and Robert Jernigan


Protein Actions: Principles and Modeling describes the basic principles of protein molecules—their structures; their folding, binding, and aggregation; their dynamics and mechanisms; and their evolution—as well as the methods of modeling them, including bioinformatics, physics-based computer simulations, and the tools of drug discovery. The book contains bold illustrations designed to help introduce and convey fundamental principles to readers from either biology or physics backgrounds. Principles and models are emphasized, as well as computational methods for simulating protein actions, and some chapters contain appendices that elaborate on advanced material. This text is ideal for graduates, advanced undergraduates, and any professional who seeks an introduction to the biological, chemical, and physical properties of proteins.

Book Summary

Protein Actions: Principles and Modeling is aimed at graduates, advanced undergraduates, and any professional who seeks an introduction to the biological, chemical, and physical properties of proteins. Broadly accessible to biophysicists and biochemists, it will be particularly useful to student and professional structural biologists and molecular biophysicists, bioinformaticians and computational biologists, biological chemists (particularly drug designers) and molecular bioengineers.

The book begins by introducing the basic principles of protein structure and function. Some readers will be familiar with aspects of this, but the authors build up a more quantitative approach than their competitors. Emphasizing concepts and theory rather than experimental techniques, the book shows how proteins can be analyzed using the disciplines of elementary statistical mechanics, energetics, and kinetics. These chapters illuminate how proteins attain biologically active states and the properties of those states. The book ends with a synopsis the roles of computational biology and bioinformatics in protein science.  The ISBN is 9780815341772.

Contents include:

1. Proteins are Polymers that Fold into Specific Structures
2. Proteins Perform Cellular Functions
3. Proteins Have Stable Equilibrium Conformations
4. Protein Binding Leads to Biological Actions
5. Folding and Aggregation Are Cooperative Transitions
6. The Principles of Protein Folding Kinetics
7. Proteins Evolve
8. Bioinformatics: Insights from Protein Sequences
9. Protein Geometries and Energetics
10. Molecular Simulations and Conformational Sampling
11. Predicting Protein Structures from Sequences
12. Biological Actions Arise from Protein Motions
13. Molecular Modeling for Drug Discovery

To view a sample portion of a chapter, please visit

Congratulations, Bob !

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