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Jonathan Mochel

Jon P Mochel

Position
  • Associate Professor of Pharmacology
  • European Veterinary Specialist in Pharmacology and Toxicology
Department
  • Biomedical Sciences
Education and Certifications
Veterinary Degree (DEFV): 2006
Masters in Clinical Pharmacology and Pharmacokinetics: 2006
Doctorate in Veterinary Medicine (DVM): 2007
Small Animal Internal Medicine and Surgery Internship: 2008
Master of Sciences in Pharmacology (MSc): 2009
Pharmacology and Toxicology Residency (Dipl. ECVPT): 2013
PhD in Pharmacology: 2015

Research Focus and Interests
Clinical Pharmacology
Pharmacokinetics and Pharmacodynamic Modeling
Cardiovascular Research
Translational Medicine (One Health)

Memberships
Co-Founder and President, Animal Health Modeling and Simulation Society
Fellow, American Academy of Veterinary Pharmacology and Therapeutics
Counselor, American Academy of Veterinary Pharmacology and Therapeutics
Member, International Society of Pharmacometrics
Member, American Association of Pharmaceutical Scientists
Member, American Gastroenterology Association
Member, European Association for Veterinary Pharmacology and Toxicology
Member, European Federation for Pharmaceutical Sciences, Network on Veterinary Medicines
Member, Charitable organization Notre-Dame de Lourdes

Selected Publications (last 4 years)
Bieth B, Bornkamp B, Toutain C, Garcia R, Mochel JP. Multiple comparison procedure and modeling: a versatile tool for evaluating dose-response relationships in veterinary pharmacology - a case study with furosemide. J Vet Pharmacol Ther. 2016 Dec;39(6):539-546. doi: 10.1111/jvp.12313. PubMed [citation] PMID: 27166146 
Pelligand L, Soubret A, King JN, Elliott J, Mochel JP. Modeling of Large Pharmacokinetic Data Using Nonlinear Mixed-Effects: A Paradigm Shift in Veterinary Pharmacology. A Case Study With Robenacoxib in Cats. CPT Pharmacometrics Syst Pharmacol. 2016 Oct 22. doi: 10.1002/psp4.12141. [Epub ahead of print] PubMed [citation] PMID: 27770596 
Lin Z, Gehring R, Mochel JP, Lavé T, Riviere JE. Mathematical modeling and simulation in animal health - Part II: principles, methods, applications, and value of physiologically based pharmacokinetic modeling in veterinary medicine and food safety assessment. J Vet Pharmacol Ther. 2016 Oct;39(5):421-38. doi: 10.1111/jvp.12311. Review. PubMed [citation] PMID: 27086878 
Dencker L, Hellmann K, Mochel JP, Senel S, Linden Hans, Vendrig D, Schmerold I Position Paper: EUFEPS Network on Veterinary Medicines Initiative. Eur J Pharm Sci. 2016 Aug 25; 91:I-VII. 
Riviere JE, Gabrielsson J, Fink M, Mochel J. Mathematical modeling and simulation in animal health. Part I: Moving beyond pharmacokinetics. J Vet Pharmacol Ther. 2016 Jun;39(3):213-23. doi: 10.1111/jvp.12278. Review. PubMed [citation] PMID: 26592724 
Mochel JP, Fink M, Peyrou M, Soubret A, Giraudel JM, Danhof M. Pharmacokinetic/Pharmacodynamic Modeling of Renin-Angiotensin Aldosterone Biomarkers Following Angiotensin-Converting Enzyme (ACE) Inhibition Therapy with Benazepril in Dogs. Pharm Res. 2015 Jun;32(6):1931-46. doi: 10.1007/s11095-014-1587-9. PubMed [citation] PMID: 25446774 
Mochel JP, Danhof M. Chronobiology and Pharmacologic Modulation of the Renin-Angiotensin-Aldosterone System in Dogs: What Have We Learned? Rev Physiol Biochem Pharmacol. 2015;169:43-69. doi: 10.1007/112_2015_27. Review. PubMed [citation] PMID: 26428686 
Mochel JP, Fink M, Bon C, Peyrou M, Bieth B, Desevaux C, Deurinck M, Giraudel JM, Danhof M. Influence of feeding schedules on the chronobiology of renin activity, urinary electrolytes and blood pressure in dogs. Chronobiol Int. 2014 Jun;31(5):715-30. doi: 10.3109/07420528.2014.897711. PubMed [citation] PMID: 24654920 
Mochel JP, Fink M, Peyrou M, Desevaux C, Deurinck M, Giraudel JM, Danhof M. Chronobiology of the renin-angiotensin-aldosterone system in dogs: relation to blood pressure and renal physiology. Chronobiol Int. 2013 Nov;30(9):1144-59. doi: 10.3109/07420528.2013.807275. PubMed [citation] PMID: 23931032 
Fink M, Letellier I, Peyrou M, Mochel JP, Jung M, King JN, Gruet P, Giraudel JM. Population pharmacokinetic analysis of blood concentrations of robenacoxib in dogs with osteoarthritis. Res Vet Sci. 2013 Oct;95(2):580-7. doi: 10.1016/j.rvsc.2013.04.021. PubMed [citation] PMID: 23726662 
Mochel JP, Gabrielsson J, Collard W, Fink M, Gehring R, Laffont C, Liu Y, Martin-Jimenez T, Pelligand L, Steimer JL, Toutain PL, Whittem T, Riviere J. Animal Health Modeling & Simulation Society: a new society promoting model-based approaches in veterinary pharmacology. J Vet Pharmacol Ther. 2013 May 29. doi: 10.1111/jvp.12060. [Epub ahead of print] PubMed [citation] PMID: 23713757 
Mochel JP, Peyrou M, Fink M, Strehlau G, Mohamed R, Giraudel JM, Ploeger B, Danhof M. Capturing the dynamics of systemic Renin-Angiotensin-Aldosterone System (RAAS) peptides heightens the understanding of the effect of benazepril in dogs. J Vet Pharmacol Ther. 2013 Apr;36(2):174-80. doi: 10.1111/j.1365-2885.2012.01406.x. PubMed [citation] PMID: 22568394 
Mochel JP, Fink M. Response to letter from Atkins et al. Capturing the dynamics of systemic Renin-Angiotensin-Aldosterone System (RAAS) peptides heightens the understanding of the effect of benazepril in dogs J Vet Pharmacol Ther. 2012 Sept 11; 35:516-518.

Contact Info

2448 Lloyd
1809 S. Riverside Drive
Ames
,
Iowa
50011-1250

Education

  • Ph.D., Pharmacology and Toxicology, Leiden University, The Netherlands, 2014