
Julien Roche
Position
- Assistant Professor
Department
- Biochemistry, Biophysics, and Molecular Biology
We study the mechanisms of folding, activation, fibrillation and evolution of proteins involved in neurodegenerative and infectious diseases. We use a combination of Nuclear Magnetic Resonance (NMR) spectroscopy, X-ray crystallography, molecular dynamics simulations and bioinformatics techniques to characterize the structural and functional properties of these proteins at an atomistic level. The detailed characterization of these complex mechanisms provides a molecular basis for the development of new therapeutic approaches.
Related projects include the study of intrinsically disordered proteins, the characterization of amyloid-type peptides and the development of coarse-grained methods for protein folding simulations.
Related projects include the study of intrinsically disordered proteins, the characterization of amyloid-type peptides and the development of coarse-grained methods for protein folding simulations.
Contact Info
3116 Molecular Biology Building
Ames
,
Iowa
50011-
Email
jroche@iastate.edu
Phone
515-294-6437
Social Media and Websites
Education
- Ph.D., Center for Structural Biology, Montpellier, France
- M.S., Biophysics, Univ. of Montpellier, France
- B.S., Biology, Univ. of Montpellier, France